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Synthesis of new thieno and pyrazolo[2,1]benzothiazepine derivatives with potential antidepressant properties
Author(s) -
Vega S.,
Díaz J. A.,
Darias V.,
Mateo C. C. SÁNchez
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370226
Subject(s) - chemistry , tricyclic , antidepressant , stereochemistry , combinatorial chemistry , psychiatry , psychology , anxiety
In this paper we describe a series of new thieno and pyrazolo[2,1]benzothiazepine derivatives 7a‐o which were synthesized by two different methods both starting from the previously described tricyclic alcohols 1–3 . Several components of this series were effective p. o. (per os, orally) in different pharmacological tests currently employed in the evaluation of antidepressant activity.