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Studies on the chemistry of thienoannelated O,N ‐ and S,N ‐containing heterocycles. 17. Preparation of 1 H ‐thieno[2,3‐b][1,4]thiazine‐1‐carboxarnides as smooth muscle relaxants
Author(s) -
Schreder Maria E.,
Erker Thomas
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370220
Subject(s) - chemistry , thiazine , moiety , quinoline , reactivity (psychology) , stereochemistry , indoline , urea , isoquinoline , guanidine , combinatorial chemistry , medicinal chemistry , organic chemistry , medicine , alternative medicine , pathology
A new series of substituted thieno[1,4]thiazines with an urea moiety has been designed. The synthesis and results of replacement of the quinoline and indoline moieties of lead structure 1 are described. The key step in preparation was the substitution with 4‐nitrophenyl chloroformate to obtain the required reactivity for substitution with diamines. Structural modifications of the amino side chain with the aim of finding tissue specific compounds were carried out. Pharmacological testings explored the presumed calcium‐channel‐antagonistic and potassium‐channel‐opening activities.