A novel and facile reaction to  N  6 ‐alkylated adenosine  via  benzotriazole as a synthetic auxiliary | Zendy

Afify Hanan M. N. M. | Zendy; Pedersen Erik B. | Zendy; Zahran Magdy A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A novel and facile reaction to N 6 ‐alkylated adenosine via benzotriazole as a synthetic auxiliary

Author(s) -

Afify Hanan M. N. M.,

Pedersen Erik B.,

Zahran Magdy A.

Publication year - 2000

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570370218

Subject(s) - chemistry , benzotriazole , alkylation , adenosine , sodium borohydride , adduct , aldehyde , adenosine receptor , stereochemistry , medicinal chemistry , combinatorial chemistry , agonist , organic chemistry , receptor , catalysis , biochemistry

The reaction of benzotriazole with aliphatic, aromatic or heteroaromatic aldehyde and adenosine leads to a benzotriazole adduct which is reduced with sodium borohydride to the corresponding N 6 ‐alkylated adenosine derivatives. This procedure is also utilized in a new route to N 6 ‐(3‐iodobenzyl)adenosine‐5′‐ N ‐methyluronamide (IB‐MECA) which is considered an important adenosine agonist at A 3 adenosine receptors.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research