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An efficient O ‐dealkylation procedure for the synthesis of (3a s,cis )‐1,2,3,3a,8,8a‐hexahydro‐1,3a,8‐trimethylpyrrolo[2,3‐ b ]indol‐5‐yl‐3,4‐dihydro‐2(1 H )‐isoquinolinecarboxylate
Author(s) -
Gao Zhongli,
Lee Thomas B. K.,
Rauckman Barbara S.
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370216
Subject(s) - chemistry , hydrobromic acid , alkylation , lithium (medication) , bromide , halide , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis , medicine , endocrinology
The title compound is synthesized in high yields and purity from (‐)‐eserethole ( 2a ) via a lithium bromide catalyzed hydrobromic acid O ‐dealkylation procedure as the key step.