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New 1,8‐ peri ‐annelated tricyclic quinolone antibacterials
Author(s) -
Miao H.,
Cecchetti V.,
Tabarrini O.,
Fravolini A.
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370213
Subject(s) - chemistry , quinolone , tricyclic , klebsiella pneumoniae , moiety , antibiotics , antibacterial activity , stereochemistry , annulation , organic chemistry , bacteria , escherichia coli , biochemistry , genetics , biology , catalysis , gene
The synthesis of new tricyclic quinolones, resulting from peri ‐annelation of 1,2,4‐oxadiazine moiety at the N‐1/C‐8 position of the pharmacophoric quinolone nucleus, are described. None of the synthesized compounds showed interesting antibacterial activity in vitro against the tested strains, with the exception of Klebsiella pneumoniae which was susceptible to all the compounds at MIC values of 8 μg/ml.