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Synthesis of five nevirapine metabolites
Author(s) -
Grozinger Karl G.,
Byrne Denis P.,
Nummy Laurence J.,
Ridges Michael D.,
Salvagno Annette
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370203
Subject(s) - chemistry , nevirapine , combinatorial chemistry , organic chemistry , stereochemistry , human immunodeficiency virus (hiv) , virology , viral load , antiretroviral therapy , biology
Nevirapine ( 1 ) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.