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Studies on pyrrolidinones. Preparation of 1,5,6‐10b‐tetrahydro‐2 H ‐pyrrolo[1,2‐ c ]quinazoline‐3‐ones from pyroglutamic acid
Author(s) -
Ghammarti Samira El,
Rigo Benoít,
Mejdi Hechmi,
Hénichart JeanPierre,
Couturier Daniel
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370124
Subject(s) - pyrrolidinones , pyroglutamic acid , chemistry , decarboxylation , quinazoline , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , amino acid , catalysis
Abstract Tetrahydro‐2 H ‐pyrrolo[1,2‐ c ]quinazoline‐3‐ones are easily obtained from the Friedel‐Crafts cyclization of N ‐arylaminomethyl pyroglutamic acids. This reaction occurrs via an acyliminium salt formed by decarboxylation of the acid function.