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Synthesis of crown ethers containing a thiazole subcyclic unit
Author(s) -
Kim HongSeok,
Kwon IiChun,
Choi JunHyeak
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360528
Subject(s) - chemistry , thiazole , adduct , benzene , ring (chemistry) , medicinal chemistry , crown (dentistry) , potassium , hydride , unit (ring theory) , organic chemistry , hydrogen , medicine , mathematics education , mathematics , dentistry
Crown ethers containing a thiazole subcyclic unit are prepared from the reactions of 1,3‐bis[2(4‐hydroxymethylthiazoyl)]benzene with di‐ p ‐tosylates of corresponding di, tri, tetra, pentaethylene glycols in the presence of potassium hydride. However, if the cavity size in the ring system is small, [2+2] cyclization adduct also is formed.
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