A new scaffold for dipeptide β‐turn mimetics: Expeditious synthesis of an unsaturated 6,5‐fused bicyclic lactam | Zendy

Millet Régis | Zendy; Houssin Raymond | Zendy; Hénichart JeanPierre | Zendy; Rigo Benoît | Zendy

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A new scaffold for dipeptide β‐turn mimetics: Expeditious synthesis of an unsaturated 6,5‐fused bicyclic lactam

Author(s) -

Millet Régis,

Houssin Raymond,

Hénichart JeanPierre,

Rigo Benoît

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360527

Subject(s) - chemistry , lactam , dipeptide , bicyclic molecule , indolizine , scaffold , pyroglutamic acid , combinatorial chemistry , stereochemistry , carboxylic acid , organic chemistry , amino acid , biochemistry , medicine , biomedical engineering

Reported here is an easy and short synthesis of 6‐acetamido‐5‐oxo‐1,2,3,5,6,7‐hexahydro‐3‐indolizine‐carboxylic acid, originating from β‐enaminoesters derived from pyroglutamic acid. This key compound has been used as a scaffold in the synthesis of dipeptido mimetics.

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