Premium
A new scaffold for dipeptide β‐turn mimetics: Expeditious synthesis of an unsaturated 6,5‐fused bicyclic lactam
Author(s) -
Millet Régis,
Houssin Raymond,
Hénichart JeanPierre,
Rigo Benoît
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360527
Subject(s) - chemistry , lactam , dipeptide , bicyclic molecule , indolizine , scaffold , pyroglutamic acid , combinatorial chemistry , stereochemistry , carboxylic acid , organic chemistry , amino acid , biochemistry , medicine , biomedical engineering
Reported here is an easy and short synthesis of 6‐acetamido‐5‐oxo‐1,2,3,5,6,7‐hexahydro‐3‐indolizine‐carboxylic acid, originating from β‐enaminoesters derived from pyroglutamic acid. This key compound has been used as a scaffold in the synthesis of dipeptido mimetics.