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2,4,6‐Trichloropyrimidine. Reaction with sodium amide
Author(s) -
Delia Thomas J.,
Meltsner Bernard R.,
Schomaker Jennifer M.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360524
Subject(s) - chemistry , amide , nucleophile , sodium , nitrogen , organic chemistry , medicinal chemistry , catalysis
The first reaction between 2,4,6‐trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4‐amino‐2,6‐dichloropyrimidine 2 and 2‐amino‐4,6‐dichloropyrimidine 3 . Additional quantities of sodium amide failed to provide either diamino‐ or triaminopyrimidines. Instead, the strongly basic nature of sodium amide led to higher molecular products that were not characterized.