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Synthesis of 2(3 H )‐benzoxazolinone derivatives as potential beta‐3‐adrenergic receptor ligands
Author(s) -
Delhomel J. F.,
Yous S.,
Depreux P.,
Lesieur D.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360521
Subject(s) - chemistry , adrenergic receptor , lipolysis , beta (programming language) , stereochemistry , receptor , adrenergic , biochemistry , adipose tissue , computer science , programming language
Beta‐3‐subtype‐adrenoceptors mediate lipolysis and in the search for potential beta‐3‐adrenergic receptor agonists for the treatment of obesity, we designed new arylethanolamines, structures B 1 and B 2 , derived from 2(3 H )‐benzoxazolinone. To obtain these target compounds as starting materials, various N ‐benzyl‐[2(3 H )‐benzoxazolinon‐6‐yl]ethylamines were used.