Synthesis of 2(3 H )‐benzoxazolinone derivatives as potential beta‐3‐adrenergic receptor ligands | Zendy

Delhomel J. F. | Zendy; Yous S. | Zendy; Depreux P. | Zendy; Lesieur D. | Zendy

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Synthesis of 2(3 H )‐benzoxazolinone derivatives as potential beta‐3‐adrenergic receptor ligands

Author(s) -

Delhomel J. F.,

Yous S.,

Depreux P.,

Lesieur D.

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360521

Subject(s) - chemistry , adrenergic receptor , lipolysis , beta (programming language) , stereochemistry , receptor , adrenergic , biochemistry , adipose tissue , computer science , programming language

Beta‐3‐subtype‐adrenoceptors mediate lipolysis and in the search for potential beta‐3‐adrenergic receptor agonists for the treatment of obesity, we designed new arylethanolamines, structures B 1 and B 2 , derived from 2(3 H )‐benzoxazolinone. To obtain these target compounds as starting materials, various N ‐benzyl‐[2(3 H )‐benzoxazolinon‐6‐yl]ethylamines were used.

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