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The preparation of 4,5‐dihydro‐2 H ‐benz[ e ]indazoles from dilithiated 2‐tetralone phenylhydrazone and aromatic esters
Author(s) -
Angel April J.,
Finefrock Anne E.,
Williams Angela R.,
Townsend Jessica D.,
Nguyen ThuyHa V.,
Hurst Douglas R.,
Heldrich Frederick J.,
Beam Charles F.,
Badejo Ibraheem T.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360519
Subject(s) - chemistry , lithium diisopropylamide , tetralone , organic chemistry , condensation , medicinal chemistry , ion , physics , deprotonation , thermodynamics
The phenylhydrazone of 2‐tetralone was dilithiated with excess lithium diisopropylamide followed by condensation with several aromatic esters, and the resulting intermediates were acid cyclized to 4,5‐dihydro‐2 H ‐benz[ e ]indazoles.
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