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Reactions of arylglyoxals with tetrasulfur tetranitrides (S 4 N 4 ): Formation of 2‐aroyl‐5‐arylimidazoles and 2‐aroyl‐5‐aryloxazoles
Author(s) -
Kong Yung Cheol,
Kim Kyongtae
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360414
Subject(s) - chemistry , hydrate , reflux , mechanism (biology) , medicinal chemistry , organic chemistry , medicine , epistemology , philosophy , disease
Treatment of arylglyoxal monohydrates with tetrasulfur tetranitride in p ‐dioxane at reflux afforded 2‐aroyl‐5‐arylimidizoles and 2‐aroyl‐5‐aryloxazoles in 10 to 31% and 17 to 32% yields, respectively. With non‐hydrate of arylglyoxals, yields of the latter increase somewhat, whereas essentially no changes in yields of the former were observed. A mechanism is proposed for the formation of the products.