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Synthesis of pyrido[3,2‐ e ]pyrrolo[2,1‐ c ][1,2,4]triazines from pyrido[3,2‐ e ][1,2,4]triazine derivatives
Author(s) -
Savelli Francesco,
Boido Alessandro,
Ciarallo Giovanni
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360405
Subject(s) - chemistry , triazine , tricyclic , pyrrole , stereochemistry , bicyclic molecule , ring (chemistry) , combinatorial chemistry , d 1 , organic chemistry , biochemistry , receptor
In carrying on our interest in heteropolycyclic structures with biological activities, we projected the preparation of compounds containing the pyrido[3,2‐ e ][1,2,4]triazine or pyrido[2,3‐ b ][1,4]triazepine systems. The established synthetic approach for the preparation of latter system led to the triazine derivatives 5a‐f while a new bicyclic triazepine structure 6 is accomplished with difficulty. In expanding the pyridotriazine structure, we obtained derivatives of a new tricyclic structure, 5‐substituted‐6a‐ethyloxycarbonyl‐5,6,6a,7‐tetrahydropyrido[2,3‐ e ]pyrrolo[2,1‐ c ][1,2,4]triazin‐9(8 H )‐ones 8 in which the triazine ring is fused with a pyrrole nucleus. Compounds 5a‐f and 8a,b will be tested as potential CNS depressant, antiinflammatory, analgesic and antibacterial agents.