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New 2‐substituted 4‐hydroxy‐2 H ‐1,2‐benzothiazine‐3‐carboxamide 1,1‐dioxides: Spectral and pharmacological properties
Author(s) -
Maso Monica Dal,
Perillo Isabel A.,
Schapira Celia B.,
Gorzalczany Susana,
Acevedo María C.,
Sicardi Susana M.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360338
Subject(s) - chemistry , carboxamide , sulfonamide , benzothiazine , analgesic agents , analgesic , medicinal chemistry , stereochemistry , pharmacology , medicine
A series of 4‐hydroxy‐2 H ‐1,2‐benzothiazme‐3‐carboxamide 1,1‐dioxides substituted on the sulfonamide nitrogen with ethoxycarbonylalkyl, cyanoalkyl and dialkylaminoalkyl groups was synthesized. Spectroscopic properties of the obtained products were analyzed. Findings from the pharmacological study of some of the compounds as antiinflammatory and analgesic agents are reported.