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An efficient general synthesis of 1‐(benzotriazol‐1‐yl)alkyl esters
Author(s) -
Katritzky Alan R.,
Pastor Alfredo,
Voronkov Michael V.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360333
Subject(s) - chemistry , catalysis , alkyl , potassium carbonate , solvent , potassium , organic chemistry , medicinal chemistry
1‐(Benzotriazol‐1‐yl)alkyl esters 2a‐u were obtained in yields averaging 86% by the direct reaction of various aldehydes with the corresponding N ‐acylbenzotriazoles in the presence of a catalytic amount of potassium carbonate (10–25 mole %). The procedure was optimized by evaluating the effects of solvent, catalyst, temperature and other parameters.