Synthesis and reactions of fluoroaryl substituted 2‐amino‐3‐cyanopyrroles and pyrrolo[2,3‐ d ]pyrimidines

Some fluoroaryl substituted 2‐amino‐3‐cyanopyrroles 2 were synthesized from the reaction between (2‐bromo‐1‐arylalkylidene)propanedinitriles 1 and fluoroaryl substituted aromatic amines under Gewald reaction condition, which on reaction with formamide and formic acid gave 4‐aminopyrrolo[2,3‐ d ]pyrimidines 3 and pyrrolo[2,3‐ d ]‐pyrimidin‐4(3 H )‐ones 4 respectively. 4‐Chloropyrrolo[2,3‐ d ]pyrimidines 5 were prepared by chlorination of 4 with phosphorus oxychloride, which on hydrazinolysis provided 4‐hydrazinopyrrolo[2–3‐ d ]pyrirnidines 6 .