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2‐Aryl‐7,7‐dimethyl‐5,6,7,8‐tetrahydrothieno[3,2‐ c ]azepin‐4‐ones from 5,5‐dimethyl‐1,3‐cyclohexanedione
Author(s) -
Martinez Roberto,
Durán L Ma. Esther,
Cortés L César,
Avila Z J. Gustavo
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360318
Subject(s) - dimedone , chemistry , aryl , diketone , oxime , organic chemistry , medicinal chemistry , catalysis , alkyl
A novel synthesis of substituted thieno[3,2‐ c ]azepinones is described. This new approach uses 5,5‐dimethyl‐1,3‐cyclohexanedione (dimedone) as the starting material. Oxime intermediates are obtained in three steps from the aforementioned diketone. Using these intermediates, the title compounds are synthesized in moderate yields.