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A quantitative study of substituent effects on oxidative cyclization of some 2‐aryl‐substituted aldehyde thiosemicarbazones induced by ferric chloride and cupric perchlorate
Author(s) -
Noto Renato,
Meo Paolo Lo,
Gruttadauria Michelangelo,
Werber Giuseppe
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360315
Subject(s) - chemistry , substituent , perchlorate , ferric , aldehyde , chloride , medicinal chemistry , aryl , hammett equation , organic chemistry , kinetics , catalysis , reaction rate constant , ion , alkyl , physics , quantum mechanics
As a development of our previous work, we performed a kinetic study of the oxidative cyclization reaction of some 2,4‐diaryl‐substituted aldehyde thiosemicarbazones 1a‐n induced by ferric chloride and by cupric perchlorate. The results of cyclization of 1a‐n were compared to those of the corresponding 2‐methyl derivatives. The kinetic data were analyzed by means of the Hammett's equation.