Synthesis and spectral properties of 2,3‐dihydro‐2‐[( o ‐ and  p ‐substituted)anilinylidene]‐1 H ‐4‐( p ‐methylphenyl)‐7‐[( o ‐ and  p ‐methyl)phenoxy]‐1,5‐benzodiazepines | Zendy

Cortés Eduardo Cortés | Zendy; Bravo Maria Paz Sánchez | Zendy

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Synthesis and spectral properties of 2,3‐dihydro‐2‐[( o ‐ and p ‐substituted)anilinylidene]‐1 H ‐4‐( p ‐methylphenyl)‐7‐[( o ‐ and p ‐methyl)phenoxy]‐1,5‐benzodiazepines

Author(s) -

Cortés Eduardo Cortés,

Bravo Maria Paz Sánchez

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360306

Subject(s) - chemistry , aniline , medicinal chemistry , spectral properties , benzodiazepine , stereochemistry , proton nmr , organic chemistry , computational chemistry , biochemistry , receptor

A series of twelve new 2,3‐dihydro‐2‐[( o ‐ and p ‐substituted)anilinylidene]‐1 H ‐4‐( p ‐methylphenyl)‐7‐[( o ‐ and p ‐methyl)phenoxy]‐1,5‐benzodiazepines, which have potentially useful pharmacological properties, has been synthesized by condensing the 3,3‐dimercapto‐1‐( p ‐methylphenyl)‐2‐propen‐1‐one with 3,4‐diaminophenyl‐R‐phenyl ethers. Subsequently the 1 H ‐1,5‐benzodiazepine‐2‐thiones obtained were treated with the ( o ‐ and p ‐substituted)aniline. The structure of all products was corroborated by ir, 1 H nmr, 13 C nmr and ms.

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