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A Comparison of the hyphenated experiments GHMQC‐TOCSY and GHSQC‐TOCSY
Author(s) -
Hadden Chad E.,
Martin Gary E.,
Luo J.K.,
Castle Raymond N.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360233
Subject(s) - chemistry , heteronuclear molecule , resolution (logic) , quinoline , quantum , sequence (biology) , analytical chemistry (journal) , computational chemistry , stereochemistry , nuclear magnetic resonance spectroscopy , chromatography , quantum mechanics , organic chemistry , physics , artificial intelligence , biochemistry , computer science
Heteronuclear shift correlations generally may be established using either the multiple quantum‐based GHMQC experiment or, alternately, the single quantum‐based GHSQC experiment. A scant few reports contained in the literature have compared results obtained with both types of sequences. The F 1 resolution of the GHMQC and GHSQC experiments are compared using the polynuclear heteroaromatic naphtho‐[2′,1′:5,6]naphtho[2′,1′:4,5]thieno[2,3‐ c ]quinoline. Even when augmented by linear prediction in F 1 , the single quantum‐based GHSQC sequence gives better F 1 resolution than its multiple quantum counterpart. To date, no studies have compared the hyphenated analogs of these experiments, GHMQC‐ and GHSQC‐ TOCSY. Similar conclusions to GHMQC/GHSQC are drawn for the comparison of GHMQC‐ and GHSQC‐ TOCSY experiments with inverted direct responses with, and without, linear prediction. The latter is recommended whenever there is congestion in both the F 2 and F 1 frequency domains.