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Synthesis and structure of novel 4‐arylhexahydro‐1 H ,3 H ‐pyrido[1,2‐ c ]pyrimidine derivatives
Author(s) -
Herold Franciszek,
Helbin Ewa,
Król Marek,
Wolska Irena,
Kleps Jerzy
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360210
Subject(s) - chemistry , steric effects , pyrimidine , aryl , ring (chemistry) , stereochemistry , nuclear magnetic resonance spectroscopy , medicinal chemistry , spectroscopy , organic chemistry , alkyl , physics , quantum mechanics
A series of new 4‐aryl‐hexahydro‐1 H ,3 H ‐pyrido[1,2‐ c ]pyrirnidine‐1,3‐dione derivatives 4a‐k were prepared by catalytic hydrogenation of 4‐aryl‐1 H ,2 H ‐pyrido[1,2‐ c ]pyrirnidine‐1,3‐diones 3a‐k. The structures of compounds were determined by 1 H and 13 C nmr spectroscopy in solution. Steric hindrance caused twisting of the phenyl ring with respect to the pyridopyrimidine system, the effect was confirmed by X‐ray diffraction.