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Synthesis and anticonvulsant activities of 5‐(2‐Chlorophenyl)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines
Author(s) -
Fiakpui Charles Y.,
Phillips Oludotun A.,
Murthy K. S. Keshava,
Knaus Edward E.
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360208
Subject(s) - chemistry , diazepine , triethyl orthoformate , anticonvulsant , medicinal chemistry , stereochemistry , d 1 , epilepsy , ring (chemistry) , catalysis , organic chemistry , receptor , psychology , neuroscience , biochemistry
A group of 5‐(2‐chlorophenyl)‐10‐(substituted)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines 7a‐c were synthesized by the acid catalyzed reaction of 5‐(2‐chlorophenyl)‐2‐hydrazino‐3 H ‐pyrido[3,4‐ e ]‐[1,4]diazepine ( 6 ) with either trimethyl orthoformate, triethyl orthoacetate or triethyl orthobenzoate, respectively. 5‐(2‐Chlorophenyl)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepine ( 7a ) and 5‐(2‐chlo‐rophenyl)‐10‐methyl‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepine ( 7b ) exhibited good anticonvulsant activity in the subcutaneous metrazol anticonvulsant screen which serves as a model for absence (petit mal) epilepsy.