Synthesis and anticonvulsant activities of 5‐(2‐Chlorophenyl)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines | Zendy

Fiakpui Charles Y. | Zendy; Phillips Oludotun A. | Zendy; Murthy K. S. Keshava | Zendy; Knaus Edward E. | Zendy

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Synthesis and anticonvulsant activities of 5‐(2‐Chlorophenyl)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines

Author(s) -

Fiakpui Charles Y.,

Phillips Oludotun A.,

Murthy K. S. Keshava,

Knaus Edward E.

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360208

Subject(s) - chemistry , diazepine , triethyl orthoformate , anticonvulsant , medicinal chemistry , stereochemistry , d 1 , epilepsy , ring (chemistry) , catalysis , organic chemistry , receptor , psychology , neuroscience , biochemistry

A group of 5‐(2‐chlorophenyl)‐10‐(substituted)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepines 7a‐c were synthesized by the acid catalyzed reaction of 5‐(2‐chlorophenyl)‐2‐hydrazino‐3 H ‐pyrido[3,4‐ e ]‐[1,4]diazepine ( 6 ) with either trimethyl orthoformate, triethyl orthoacetate or triethyl orthobenzoate, respectively. 5‐(2‐Chlorophenyl)‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepine ( 7a ) and 5‐(2‐chlo‐rophenyl)‐10‐methyl‐7 H ‐pyrido[4,3‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepine ( 7b ) exhibited good anticonvulsant activity in the subcutaneous metrazol anticonvulsant screen which serves as a model for absence (petit mal) epilepsy.

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