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Synthesis of spiroisoindolinones by palladium‐catalyzed heterocyclization of 2‐iodobenzoyl chloride with ketimines
Author(s) -
Cho Chan Sik,
Wu Xue,
Jiang Li Hong,
Shim Sang Chul,
Kim Hong Rak
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360147
Subject(s) - chemistry , triethylamine , palladium , catalysis , acetonitrile , carbon monoxide , chloride , organic chemistry , medicinal chemistry , polymer chemistry
2‐Iodobenzoyl chloride reacts with ketimines in acetonitrile at 100° under carbon monoxide pressure in the presence of a catalytic amount of a palladium catalyst together with triethylamine to afford the corresponding spiroisoindolinones in high yields.