Synthesis of certain 5‐substituted thieno[2,3‐ b ]thiophene‐2‐sulfonamides and thieno[2,3‐ b ]thiophene‐2‐sulfonamide 6,6‐dioxides | Zendy

Chen HwangHsing | Zendy; May Jesse A. | Zendy; Lynch Vincent M. | Zendy

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Synthesis of certain 5‐substituted thieno[2,3‐ b ]thiophene‐2‐sulfonamides and thieno[2,3‐ b ]thiophene‐2‐sulfonamide 6,6‐dioxides

Author(s) -

Chen HwangHsing,

May Jesse A.,

Lynch Vincent M.

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360138

Subject(s) - thiophene , chemistry , sulfonamide , carbonic anhydrase , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , enzyme

A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5‐substituted thieno[2,3‐ b ]thiophene‐2‐sulfonamides provided the first examples of thiophene[2,3‐ b ]thiophene‐2‐sulfonarnide 6,6‐dioxides. These cyclic vinyl sulfones readily underwent addi tion to give predominately that 4,5‐ cis addition product.

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