Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 2 . Reaction of methanetricarboxylates with 2‐aminopyridine, 2‐aminopyrimidine, 2‐aminothiazole and 2‐aminobenzothiazole | Zendy

Kutyrev Alexander | Zendy; Kappe Thomas | Zendy

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Methanetricarboxylates as key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 2 . Reaction of methanetricarboxylates with 2‐aminopyridine, 2‐aminopyrimidine, 2‐aminothiazole and 2‐aminobenzothiazole

Author(s) -

Kutyrev Alexander,

Kappe Thomas

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360136

Subject(s) - chemistry , 2 aminopyridine , reagent , combinatorial chemistry , 4 aminopyridine , organic chemistry , primary (astronomy) , reaction conditions , catalysis , physics , astronomy , potassium channel , biology , biophysics

The reaction of methanetricarboxylates 1a,b with 2‐aminopyridine, 2‐aminopyrimidine, 2‐aminothiazole as well as 2‐aminobenzothiazole yields corresponding heteroarylcarboxylic acid esters 2a,b , 5 , 8 , 11a,b . These heterocyclic esters were used as a starting material by the reaction with primary amines to obtaining a number of heteroarylcarboxylic amides 4a‐j , 6 , 10a,b , 13a‐g bearing various substituents on the carboxamide group.

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