Preparation of 1,2‐disubstituted‐3‐hydroxy‐4(1 H )‐quinolinones and the influence of substitution on the course of cyclization | Zendy

Hradil Pavel | Zendy; Hlaváč Jan | Zendy; Lemr Karel | Zendy

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Preparation of 1,2‐disubstituted‐3‐hydroxy‐4(1 H )‐quinolinones and the influence of substitution on the course of cyclization

Author(s) -

Hradil Pavel,

Hlaváč Jan,

Lemr Karel

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360121

Subject(s) - chemistry , steric effects , phenacyl , substitution (logic) , boiling , scope (computer science) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computer science , programming language

Synthesis of 1,2‐disubstituted‐3‐hydroxy‐4(1 H )‐quinolinones by the cyclization of N ‐substituted phenacyl or acetonyl anthranilates is described. Two methods were employed for cyclization of anthranilates. Heating in polyphosphoric acid has a wide scope of applicability. The thermal cyclization in boiling N ‐methylpyrrolidone is limited by steric effect.

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