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Synthesis of novel 5‐aryl‐6‐cyano‐3 H ,8 H ‐pyrido[2,3‐ d ]pyrimidine‐4,7‐diones in the reaction of 6‐amino‐4‐pyrimidinones with benzaldehyde and ethyl cyanoacetate
Author(s) -
Quiroga Jairo,
Alvarado Mario,
Insuasty Braulio,
Nogueras Manuel,
Sánchez Adolfo,
López M. Dolores
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360117
Subject(s) - chemistry , pyrimidinones , benzaldehyde , dept , pyrimidine , aryl , ethyl cyanoacetate , stereochemistry , proton nmr , oxazolidine , medicinal chemistry , organic chemistry , malononitrile , catalysis , alkyl
Abstract The title compounds 4 and 5 have been prepared in one‐step reaction from 6‐amino‐4‐pyrimidinones 1 , the corresponding 4‐substituted benzaldehyde 2 and ethyl cyanoacetate 3 in very good yields. The structure of the final compounds was determined on the basis of nmr measurements, especially by 1 H, 1 H‐, 1 H, 13 C COSY, and DEPT.