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Synthesis, characterization and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 5‐aryl‐2‐phenyl‐6,7‐dihydropyrazolo[1,5‐ a ]pyrimidines
Author(s) -
Quiroga Jairo,
Insuasty Braulio,
Hormaza Angelina,
Gamenara Daniela,
Dominguez Laura,
Saldaña Jenny
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360102
Subject(s) - nippostrongylus brasiliensis , chemistry , anthelmintic , in vitro , pyridine , aryl , stereochemistry , d 1 , organic chemistry , biochemistry , parasite hosting , ecology , alkyl , receptor , biology , world wide web , computer science
Several new pyrazolo[1,5‐ a ]pyrimidines were obtained from the reaction of 1 H ‐5‐amino‐3‐phenylpyrazole ( 1 ) with β‐dimethylaminopropiophenones 2 in pyridine. The structure elucidation of 6,7‐dihydropyrazolo[1,5‐ a ]pyrimidines 3 is based on nmr measurements. These compounds showed moderate anthelmintic in vitro activity against the Nipposirongylus brasiliensis model.