Studies on the chemistry of thienoannelated o,n ‐ and s,n‐ containing heterocycles. 16 . Synthesis of some thieno[1,4]thiazine derivatives with potential calcium antagonistic activity

Substituted thieno[1,4]thiazine derivatives have been synthesized. They are thienoanalogues of compound 3 [2], a potent cerebral protectant and calcium antagonist. Research activities concentrate on the preparation of structurally modified compounds of 3 to minimize its undesirable symptoms.