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Studies on the synthesis of some dihydropyridine derivatives possessing calcium antagonistic activity
Author(s) -
Kilcigil Gülgün Ayhan,
Ertan Rahmiye,
Özbey Süheyla,
Kendi Engin
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350645
Subject(s) - chemistry , dihydropyridine , ring (chemistry) , nifedipine , calcium , stereochemistry , combinatorial chemistry , organic chemistry
In this study, it is aimed to investigate the synthesis and the calcium antagonistic activity of some flavone derivatives which contain the 1,4‐dihydropyridine ring system at the A ring of the flavone nucleus. For this purpose we first synthesized 6‐formylflavone and then twelve 1,4‐dihydropyridine derivatives were synthesized by the reaction of 6‐formylflavone with alkylacetoacetates, acetoacetanilide and methyl or ethyl aminocrotonate. Conformational analysis was performed for compound 3a . The calcium antagonistic activity of compound 2a was examined using nifedipine as the reference compound.