Premium
Synthesis of isoindolo[1,3]benzoxazine derivatives through intramolecular arylation of N‐ acyliminium ions
Author(s) -
Hucher Nicolas,
Daïch Adam,
Decroix Bernard
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350644
Subject(s) - chemistry , isoindole , intramolecular force , phenols , ion , fluoride , medicinal chemistry , organic chemistry , combinatorial chemistry , inorganic chemistry
[1,3]Benzoxazines annulated to isoindole as 3 and 4 have been synthesized in three steps from N ‐chloromethylphthalimide 5 and substituted phenols 6 . The key step was the acid‐catalyzed cyclization of ω‐carbinol lactams 8 and 9.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom