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Synthesis and reduction of thieno[2′,3′(3′,2′ or 3′,4′):5,6]‐azocino[2,1‐ a ]isoindole‐7, 13‐diones
Author(s) -
Othman Mohamed,
Pigeon Pascal,
Decroix Bernard
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350635
Subject(s) - isoindole , chemistry , acetic acid , wittig reaction , organic chemistry , stereochemistry , medicinal chemistry , combinatorial chemistry
A synthesis of the thieno[2′,3′(3′,2′ or 3′,4′):5,6]azocino[2,1‐ a ]isoindole‐7,13‐diones 6a‐c was developed from N ‐thienylethylphthalimides 3a‐c using a Wittig reaction followed by a Friedel‐Crafts cyclization of acetic acid derivatives 5a‐c . Reduction of ketones 6a‐c into alcohols 7a‐c was stereo specific.