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Pyridazines. XV . Synthesis of 6‐aryl‐5‐amino‐3(2 H )‐pyridazinones as potential platelet aggregation inhibitors
Author(s) -
Estevez Isabel,
Raviña Enrique,
Sotelo Eddy
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350634
Subject(s) - chemistry , pyridazine , platelet aggregation , aryl , stereochemistry , platelet , organic chemistry , alkyl , immunology , biology
Several 3(2 H )‐pyridazinones with amino groups at the 5‐position of the pyridazine nucleus have been prepared. The 6‐aryl‐5‐halo‐3(2 H )‐pyridazinones obtained from mucochloric and mucobromic acid lead to the corresponding 5‐alkylamino‐3(2 H )‐pyridazinones, which were tested as platelet aggregation inhibitors.