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Synthesis of 4‐aryl‐2,3,6,7‐tetrahydro‐1 H ‐pyrimido[4,5‐ b ][1,4]‐diazepin‐6‐ones from 4,5‐diamino‐1 H ‐pyrimidin‐6‐ones and 1‐aryl‐3‐(dimethylamino)‐1‐propanones
Author(s) -
Insuasty Braulio,
Quiroga Jairo,
Argoti Juan Carlos,
Gómez Samuel,
Martínez Roberto,
Angeles Enrique,
Gabiño Rubén,
Nogueras Manuel,
Sánchez Adolfo
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350629
Subject(s) - chemistry , aryl , stereochemistry , dept , medicinal chemistry , organic chemistry , alkyl
Abstract The reaction of 1‐aryl‐3‐(dimethylamino)‐1‐propanones 1 with one equivalent of 4,5‐diamino‐1 H ‐pyrimidin‐6‐ones 2 , in acidic medium, leads to the formation of 4‐aryl‐2,3,6,7‐tetrahydro‐1 H ‐pyrimido[4,5‐ b ]‐[1,4]diazepin‐6‐ones 3 . The structure elucidation of the products is based on detail nmr analysis of experiments such as 13 C, 1 H and DEPT including selective 13 C{ 1 H} decoupling experiments.