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Synthesis of indolizidinediones annelated to a furan ring
Author(s) -
Szemes Fridrich,
Marchalín ŠTefan,
Bar Nathalie,
Decroix Bernard
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350625
Subject(s) - chemistry , furan , yield (engineering) , selectivity , ring (chemistry) , organic chemistry , medicinal chemistry , stereochemistry , catalysis , materials science , metallurgy
The furo[2,3(or 3,2)‐ f ]indolizidinediones 4a,b were synthesized in five steps from glutamic acid in good yield. The ketones were converted into trans alcohols 5a,b or oximes 6a,b (either as syn‐anti mixture or as single isomer). The selectivity of these reactions is discussed.