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Synthesis of the bi‐heterocyclic parent ring system 1,2,4‐triazolo[4,3‐ b ][1,2,4,5]tetrazine and some 3,6‐disubstituted derivatives
Author(s) -
Chavez David E.,
Hiskey Michael A.
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350616
Subject(s) - tetrazine , chemistry , ring (chemistry) , reagent , medicinal chemistry , stereochemistry , organic chemistry
The synthesis of the previously unknown parent ring system was developed. Treatment of 3‐hydrazino‐1,2,4,5‐tetrazine ( 4 ) with diethoxymethyl acetate gave the parent ring system. Similar treatment of 3‐(3,5‐dimethylpyrazol‐1‐yl)‐6‐hydrazino‐1,2,4,5‐tetrazine ( 2 ) with one carbon cyclizing reagents gave 3,6‐di‐substituted derivatives of the 1,2,4‐triazolo‐1,2,4,5‐tetrazine ring system.