Premium
Synthesis of 6‐cyanopyrido[2,3‐ d ]pyrimidinones in the reaction of 6‐amino‐4‐pyrimidinones with arylidene derivatives of malonodinitrile
Author(s) -
Quiroga Jairo,
Alvarado Mario,
Insuasty Braulio,
Nogueras Manuel,
Sánchez Adolfo,
Cobo Justo
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350612
Subject(s) - pyrimidinones , chemistry , dept , stereochemistry , aryl , organic chemistry , alkyl
This paper describes the synthesis of a new series of 7‐amino‐5‐aryl‐6‐cyano‐5,8‐dihydropyrido‐[2,3‐ d ]pyrimidin‐4(3 H )‐ones 3 from the reaction of 6‐amino‐4‐pyrimidinones 1 with arylidene derivatives of malonodinitrile 2 . The structure of the final compounds was determined on the basis of nmr measurements, especially by 1 H, 1 H‐, 1 H, 13 C COSY, DEPT, HMBC and HMQC experiments.