Premium
Synthesis of 5‐amino‐1,2,3,4‐tetrahydrobenzo[ b ][1,7]naphthyridines and 2,3,4,4a,5,6‐hexahydrobenzo[c][2,6]naphthyridines
Author(s) -
Giudice Maria Rosaria Del,
Mustazza Carlo,
Ferretti Rosella,
Borioni Anna,
Gatta Franco
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350422
Subject(s) - chemistry , acetylcholinesterase , stereochemistry , inhibitory postsynaptic potential , combinatorial chemistry , organic chemistry , enzyme , neuroscience , biology
This paper describes the synthesis of some 5‐amino‐1,2,3,4‐tetrahydrobenzo[ b ][1,7]naphthyridines and 2,3,4,4a,5,6‐hexahydrobenzo[ c ][2,6] naphthyridines starting from anilines and 1‐benzyl‐4‐ethoxycarbonylpiperidin‐3‐one. The compounds were prepared in order to study their potential acetylcholinesterase inhibitory activity.