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A facile synthesis of cyanophenothiazines
Author(s) -
MarivingtMounir Céacile,
Mettey Yvette,
Vierfond JeanMichel
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350410
Subject(s) - chemistry , intramolecular force , condensation , ring (chemistry) , smiles rearrangement , substitution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , physics , computer science , thermodynamics , programming language
A one‐pot synthesis of 1, 3 and 4‐cyanophenothiazines and a two‐step approach to 2‐cyanoisomer have been developed. The condensation of 2‐aminobenzenethiol and 2,3 or 3,4‐dihalogenobenzonitriles followed by Smiles rearrangement or by intramolecular aromatic substitution gave the desired ring systmes.