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A new expedient route to 2,6‐diaryl‐3‐cyano‐4‐(trifluoromethyl)pyridines
Author(s) -
Yamaguchi Yoshihiro,
Katsuyama Isamu,
Funabiki Kazumasa,
Matsui Masaki,
Shibata Katsuyoshi
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350405
Subject(s) - chemistry , trifluoromethyl , acetonitrile , aryl , nitrile , potassium , medicinal chemistry , organic chemistry , alkyl
1‐Aryl‐4,4,4‐trifluoro‐1,3‐butanediones 1 react with β‐amino‐β‐arylacrylonitrile 2 , readily available from acetonitrile with aryl nitriles in the presence of potassium t ‐butoxide, to afford the corresponding 2,6‐diaryl‐3‐cyano‐4‐(trifluoromethyl)pyridines 3 in moderate to excellent yields.