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Synthesis of functionalized 3‐pyridyl methyl ketones
Author(s) -
Wright S. W.,
Hageman D. L.,
McClure L. D.
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350335
Subject(s) - chemistry , hydrolysis , ether , vinyl ether , organic chemistry , in situ , palladium , catalysis , copolymer , polymer
A synthesis of 3‐pyridyl methyl ketones is described that employs a palladium‐catalyzed olefination of 3‐bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether in situ . This method has been applied to bromoquinoline substrates as well. The reaction is compatible with a variety of functional groups.
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