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Studies on pyrrolidinones. Synthesis of N ‐benzhydrylpyroglutamic acids and esters
Author(s) -
Rigo Benoît,
Gautret Philippe,
Legrand Anne,
Hénichart Jean Pierre,
Couturier Daniel
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350312
Subject(s) - chemistry , saponification , trimethylsilyl , hydrolysis , pyrrolidinones , alkylation , organic chemistry , pyroglutamic acid , catalysis , amino acid , biochemistry
Catalyzed N ‐alkylation of N,O ‐bistrimethylsilyl pyroglutamic acid with trimethylsilyl benzhydryl ethers yields trimethylsilyl N ‐benzhydrylpyroglutamates. Hydrolysis of these compounds or saponification of the methyl esters gives the corresponding acids.