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Syntheses of new pyridonecarboxylic acid derivatives containing 3‐,5‐ or 6‐quinolyl substituents at N‐1 and their anti‐HIV‐RT activities
Author(s) -
Oh YoonSeok,
Lee ChiWbo,
Chung YongHo,
Yoon SungJune,
Cho Sung Hye
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350309
Subject(s) - chemistry , human immunodeficiency virus (hiv) , in vitro , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , virology , biology
A series of new pyridonecarboxylic acid derivatives containing 3‐, 5‐ or 6‐quinolyl substituents at N‐1 were synthesized and their in vitro anti‐HIV‐RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.