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Reaction of 5‐aminopyrazoles with β‐dimethylaminopropiophenones. Synthesis of new pyrazolo[3,4‐ b ]pyridines
Author(s) -
Quiroga J.,
Insuasty B.,
Cruz S.,
Hernandez P.,
Bolaños A.,
Moreno R.,
Hormaza Angelina,
de Almeida Regina H. S.
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350213
Subject(s) - chemistry , pyridine , aryl , medicinal chemistry , stereochemistry , organic chemistry , alkyl
Several new pyrazolo[3,4‐ b ]pyridines were obtained from the reaction of 5‐amino‐1‐aryl‐3‐methylpyrazoles 1 with β‐dimemylaminopropiophenones 2 in pyridine. The structure elucidation of 4,5‐dihydropyrazolo[3,4‐ b ]pyridines 3 is based on nmr measurements and X‐ray diffraction. The treatment of compounds 3 with N ‐bromosuccinimide led to the formation of pyrazolo[3,4‐ b ]pyridines 4 .