Synthesis and central nervous system stimulant activity of 5,8‐methanoquinazolines fused with 1,2,4‐triazole, tetrazoleand 1,2,4‐triazine | Zendy

Nagai ShinIcbi | Zendy; Ueda Taisei | Zendy; Sugiura Satoe | Zendy; Nagatsu Akito | Zendy; Murakami Nobutoshi | Zendy; Sakakibara Jinsaku | Zendy; Fujita Michiko | Zendy; Hotta Yoshiki | Zendy

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Synthesis and central nervous system stimulant activity of 5,8‐methanoquinazolines fused with 1,2,4‐triazole, tetrazoleand 1,2,4‐triazine

Author(s) -

Nagai ShinIcbi,

Ueda Taisei,

Sugiura Satoe,

Nagatsu Akito,

Murakami Nobutoshi,

Sakakibara Jinsaku,

Fujita Michiko,

Hotta Yoshiki

Publication year - 1998

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570350211

Subject(s) - chemistry , stimulant , tetrazole , triazole , triazine , 1,2,4 triazole , central nervous system , stereochemistry , combinatorial chemistry , medicinal chemistry , pharmacology , organic chemistry , neuroscience , psychology , medicine

5,8‐Methanoquinazolines fused with 1,2,4‐triazole 4–5 , tetrazole 6 , and 1,2,4‐triazine 8 were prepared starting from 2‐hydrazino‐5,8‐methanoquinazoline 3 . Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.

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