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Synthesis and central nervous system stimulant activity of 5,8‐methanoquinazolines fused with 1,2,4‐triazole, tetrazoleand 1,2,4‐triazine
Author(s) -
Nagai ShinIcbi,
Ueda Taisei,
Sugiura Satoe,
Nagatsu Akito,
Murakami Nobutoshi,
Sakakibara Jinsaku,
Fujita Michiko,
Hotta Yoshiki
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350211
Subject(s) - chemistry , stimulant , tetrazole , triazole , triazine , 1,2,4 triazole , central nervous system , stereochemistry , combinatorial chemistry , medicinal chemistry , pharmacology , organic chemistry , neuroscience , psychology , medicine
5,8‐Methanoquinazolines fused with 1,2,4‐triazole 4–5 , tetrazole 6 , and 1,2,4‐triazine 8 were prepared starting from 2‐hydrazino‐5,8‐methanoquinazoline 3 . Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.