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Synthesis and central nervous system stimulant activity of camphor‐1,2,4‐benzotriazines fused with five and six‐membered heterocycles
Author(s) -
Nagai ShinIchi,
Ueda Taisei,
Takamura Masatoshi,
Nagatsu Akito,
Murakami Nobutoshi,
Sakakibara Jinsaku
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350205
Subject(s) - chemistry , camphor , imidazole , stimulant , pyrimidine , central nervous system , stereochemistry , triazine , organic chemistry , pharmacology , neuroscience , psychology , medicine
Novel camphor‐1,2,4‐triazines fused with imidazole 2–3 , thiadiazole 4 , 1,2,4‐triazole 7 , pyrimidine 9–13 and 1,3,5‐triazine 14 , were synthesized starting from (5 R ,8 S )‐3‐amino‐5,9,9‐trimethyl‐5,6,7,8‐tetrahydro‐5,8‐methano‐1,2,4‐benzotriazine 1 . Evaluation of central nervous system stimulant activity demonstrated that the presence of a N‐N group at C‐3 position of 1,2,4‐benzotriazine will be essential for the activity.