Synthesis and central nervous system stimulant activity of camphor‐1,2,4‐benzotriazines fused with five and six‐membered heterocycles | Zendy

Nagai ShinIchi | Zendy; Ueda Taisei | Zendy; Takamura Masatoshi | Zendy; Nagatsu Akito | Zendy; Murakami Nobutoshi | Zendy; Sakakibara Jinsaku | Zendy

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Synthesis and central nervous system stimulant activity of camphor‐1,2,4‐benzotriazines fused with five and six‐membered heterocycles

Author(s) -

Nagai ShinIchi,

Ueda Taisei,

Takamura Masatoshi,

Nagatsu Akito,

Murakami Nobutoshi,

Sakakibara Jinsaku

Publication year - 1998

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570350205

Subject(s) - chemistry , camphor , imidazole , stimulant , pyrimidine , central nervous system , stereochemistry , triazine , organic chemistry , pharmacology , neuroscience , psychology , medicine

Novel camphor‐1,2,4‐triazines fused with imidazole 2–3 , thiadiazole 4 , 1,2,4‐triazole 7 , pyrimidine 9–13 and 1,3,5‐triazine 14 , were synthesized starting from (5 R ,8 S )‐3‐amino‐5,9,9‐trimethyl‐5,6,7,8‐tetrahydro‐5,8‐methano‐1,2,4‐benzotriazine 1 . Evaluation of central nervous system stimulant activity demonstrated that the presence of a N‐N group at C‐3 position of 1,2,4‐benzotriazine will be essential for the activity.

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