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2,4,6‐trichloropyrimidine. Reaction with 4‐substituted phenolate ions
Author(s) -
Delia Thomas J.,
Nagarajan A.
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350201
Subject(s) - chemistry , nucleophile , reactivity (psychology) , ion , product (mathematics) , medicinal chemistry , combinatorial chemistry , product distribution , organic chemistry , computational chemistry , catalysis , medicine , alternative medicine , geometry , mathematics , pathology
A systematic investigation of the reactivity of 2,4,6‐trichloropyrimidine with phenoxide nucleophiles has been conducted. Conditions have been described which lead to mono‐, di‐, and trisubstituted‐pyrimidines. Unexpected product distributions for mono‐ and disubstituted products were observed and explanations for these results are offered.