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Substituted N ‐cyanomethyl‐2‐halo‐ N ‐methylarenecarboxamides as precursors of 1,4‐benzothiazepines
Author(s) -
Dölling Wolfgang,
Perjéssy Alexander,
Schaller Ingrid,
Kolbe Alfred
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350141
Subject(s) - chemistry , ring (chemistry) , nitro , medicinal chemistry , halo , spectroscopy , stereochemistry , organic chemistry , alkyl , physics , quantum mechanics , galaxy
2‐Halogeno substituted N ‐cyanomethyl‐ N ‐methylbenzamides 1a‐1i were investigated in a correlation analysis by ir spectroscopy to determine the conformational behavior. Compound 1h gives 4‐methyl‐2‐methylthio‐8‐nitro‐5‐oxo‐4,5‐dihydro‐1,4‐benzothiazepine‐3‐carbonitrile 3 by dithiocarboxylation procedure whereas 1b was not able to react to heterocyclic seven‐membered ring system.