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Synthesis of 5‐dialkylaminothiocarbonylthiobarbituric acids and 5‐diethyiaminothiocarbonylthio‐6‐aminouracil
Author(s) -
Neilands Ojars Y A.,
Sudmale Ineta,
Schnell Barbara,
Georgieva Krassimira,
Kappe Thomas
Publication year - 1998
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570350129
Subject(s) - chemistry , potassium carbonate , derivative (finance) , betaine , salt (chemistry) , potassium , carbonate , organic chemistry , economics , financial economics
The title compounds are obtained by three different methods. The aminothiocarbonylthiolation of barbituric acids 1 and aminouracil ( 5 ) can be accomplished in one step by reaction with thiuram disulfides in the presence of potassium carbonate. On the other hand, compounds 4 can be obtained via the salt of chloro derivative 2 or the corresponding iodonium ylides 3 . The aminouracil derivative 7 was obtained in a similar fashion from 5 directly or via iodonium betaine 6 .